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Several companies with buses from Istanbul to various destinations operate from Office 3 of Istanbul's Büyük Otogar:
The Özen company runs buses to Yalvaç (Antioch-in Pisidia); Isparta (from which you can take a minibus to nearby Egirdir); and two other companies, Gebze Kooperatifi and Mahmudoglu, run buses from Istanbul to Afyon (for Midas Sehri and the lands of ancient Phrygia), Gebze, Uluborlu, Senirkent and Sarkikaraagaç.
Alphabetical List of Destinations
Full List of Offices/Perons & Companies
Istanbul Bus Terminal (Otogar) Homepage